OK now it's certainly possible to imagine a technological enhancement that could circumvent this neuronal homeostasis, such that the brain does not diminish its production of neurotransmitters in response their engineered, potentiated synaptic presence.
But as as you noted ABedlamSun, we aren't just neurochemistry in a vacuum, we learn observationally. So what I'm saying is that yes, we can try to do away with pain by augmenting neuronal processes, but I think it's functional equivalent would re-emerge as a way to keep us out of danger. For example, if you can't feel physical pain, you can't sense that you should take your hand off of a hot stove, but you can deduce that you should, based on logical reasoning. This process of deduction might adaptively become so closely allied to the action of placing your hand on the stove that it happens simultaneous with the action, just as pain. Thus, if the property of associating damage with aversion is intrinsic to humanity (cannot be done away with, if you try, it will re-emerge), why waste time and effort trying to get rid of it in the first place?
But now actually I'm thinking Odlov is right, that technology might be able to mimic this alert system in a way that we don't have to feel it, but that would similarly incentivize taking responsive action. And Odlov said the article is more about emotional pain anyway (alas I still haven't read through it). So I think what I was trying to argue is that the value of emotional pain (or any pain) is at least partially rooted in it being a felt experience, and if we do away with this, we might be missing out on something. That something, I was arguing, is the immediacy of the experience of pain. And maybe Pearce is not talking about doing away with the immediacy of feeling, but changing our incentives and conditioning mechanisms to be solely pleasure based, instead of including both pleasure and pain. Maybe this could work. What do you think?