I use AVG. I have it set to scan daily, which causes some shitty performance during the scans, but it detects everything I get, should I happen to suck for five seconds and click the wrong clicker or something.
I will say I don't like the new interface though, it runs slow as hell and is very counter intuitive. Honestly I liked it better when the AV and anti-spy ware were separate programs. I have been thinking of switching, maybe I will try avast.