Maya has the hardest interface by far.
C4D is the easiest to use, but it is expensive.
Blender is free and has a good interface, but it can't compete with C4D.
As for functionality;
Blender natively has more as far as I know.
But for modelling then it is negligible.
Obviously if you are looking to learn for school then Maya, 3Ds and blender are the only legitimate choices.