Toribash
What are the statistics for your graphics card and drivers and processor? I doubt it's because of the operating system.
Quit, probably.
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What actually happens?
You open Toribash, and then... What?
Does it suddenly climb out of your computer and jump out of the window?
Or what?
More information would help us a lot in solving this, because when you're stating that it just doesn't work on Vista, it might be anything...