Under brush dynamics I'd recommend turning off pressure opacity and instead turning on pressure size. Instead of using pressure opacity, manually switch between sub 20% and post 70% opacities when you need them. Use a large, soft, low opacity brush and several strokes to develop depth and a small, hard, and high opacity brush for details/hard edges. Also try to work on one layer, or at the very least have your color picker set to be layer independent. And zoom in a lot unless you have fine motor skills.
I used to work with pressure opacity but found the above way of working to be much faster/cleaner. I find with pressure opacity you do a lot of drawing over work you've already done to get it to look "right" instead of drawing what you want to. Vid below shares the same feelings and kinda explains why that might be:
https://youtu.be/eaH_WlD_rP4?t=727 (Also watch first two minutes of p2 of this vid if you want more examples).
Also, obligatory disclaimer that this is only the way I work (Not that I really "work" anymore >_>) and is by no means the right way to work.
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Edit: Oh right and to help with any lack of motor skills, try binding something to rotate canvas and reset canvas (Latter is Esc by default). Photoshop can rotate the canvas without destroying the image. A lot of people can draw good lines in at least one direction/angle but not all of them. In real life whenever you're drawing on a sheet of paper you usually rotate the sheet/your body so that you can always draw your best line. So you should set up Photoshop to where you can do the same (Rotating your tablet helps too, but only so much).
Last edited by GoodBox; Sep 11, 2015 at 05:29 AM.